Dr. Germain-Lee received her Bachelor's degree from Harvard University, graduating magna cum laude in Biochemical Sciences. She received her M.D. degree from the Johns Hopkins University School of Medicine and continued at Johns Hopkins for her internship and residency in Pediatrics as well as her fellowship in Pediatric Endocrinology. She has been on the faculty at Johns Hopkins since 1992 and is an Associate Professor of Pediatrics in the Division of Pediatric Endocrinology. In 2010, Dr. Germain-Lee joined the Kennedy Krieger Institute as the Director of Bone Research and Associate Director of the Bone & Osteogenesis Imperfecta Department in order to focus her clinical and research efforts on her long-standing interest in bone disorders.
Dr. Germain-Lee's clinical work and research are focused on Albright hereditary osteodystrophy and Osteogenesis Imperfecta, two rare genetic conditions involving bone abnormalities. Upon her arrival to Kennedy Krieger, Dr. Germain-Lee started the Albright Clinic in order to provide multidisciplinary care for children and adults with Albright hereditary osteodystrophy (AHO). She follows one of the largest populations of these patients. She has become extensively involved in Kennedy Krieger's renowned Osteogenesis Imperfecta (OI) Clinic which cares for a world-wide network of patients with this disorder.
Dr. Germain-Lee has spearheaded several clinical trials in AHO. She identified growth hormone deficiency to be a common problem in patients with pseudohypoparathyroidism type 1a, a subtype of AHO, and is conducting an FDA-sponsored trial evaluating the effects of growth hormone treatment on height, weight, metabolism, bone density, and quality of life in AHO. She is also investigating other clinical problems including bone abnormalities and cognitive deficits.
For both AHO and OI, Dr. Germain-Lee is conducting laboratory investigations utilizing mouse models of these conditions in tandem with clinical research studies. The goal is to develop new treatment methods which could improve the overall health and quality of life for patients with these disorders. By combining scientific investigations in the laboratory with clinical studies, she has the unique opportunity to translate scientific knowledge into therapeutic applications.
Dr. Germain-Lee is the endocrinologist for the Greenberg Center for Skeletal Dysplasias of the Johns Hopkins Institute of Genetic Medicine and for the Hunter Nelson Sturge-Weber Center at Kennedy Krieger. She has been instrumental in identifying growth hormone deficiency and thyroid hormone deficiency as potential problems in patients with Sturge-Weber Syndrome. As Vice President of the Human Growth Foundation, Dr. Germain-Lee is involved in educational and outreach programs to help children and adults affected by growth and skeletal abnormalities.
For details of Dr. Germain-Lee's research and ongoing clinical trials, please refer to: germain-lee.kennedykrieger.org/research/index.html